Last updated 14 days ago
A Phase III, Randomised Study of Adjuvant Dato-DXd in Combination With Rilvegostomig or Rilvegostomig Monotherapy Versus Standard of Care, Following Complete Tumour Resection, in Participants With Stage I Adenocarcinoma NSCLC Who Are ctDNA-positive or Have High-risk Pathological Features
660 patients around the world
Available in Spain, Brazil, United States
The primary objective of the study is to assess the efficacy and safety of adjuvant
Dato-DXd in combination with rilvegostomig relative to SoC, after complete surgical
resection (R0) in participants with Stage I adenocarcinoma NSCLC who are ctDNA-positive,
as determined by the Sponsor-designated ctDNA assay, or have at least one high-risk
pathological feature.
AstraZeneca
660Patients around the world
This study is for people with
Lung cancer
Non-small cell lung carcinoma
Requirements for the patient
From 18 Years
All Gender
Medical requirements
- Histologically documented treatment-naive Stage I (T < 4 cm, AJCC 8th ed) adenocarcinoma NSCLC.Complete surgical resection (R0) of the primary NSCLC.Unequivocal no evidence of disease at post-surgical.Pre-surgical ctDNA-positive result (Stage IA or IB) OR presence of at least one high-risk pathological feature (visceral pleural invasion (VPI), lymphovascular invasion (LVI), high-grade histology) (Stage IB only).ECOG of 0 or 1, life expectancy of > 6 months and complete recovery after surgery.Adequate bone marrow reserve and organ function.
- Sensitizing EGFR mutation and/or ALK alteration.History of non-infectious ILD/pneumonitis that required steroids, has current ILD/pneumonitis, or has suspected ILD/pneumonitis that cannot be ruled out by imaging at screening.Significant pulmonary function compromise.History of another primary malignancy within 3 years (with exceptions).Any evidence of severe or uncontrolled systemic diseases, including but not limited to bleeding diseases, active infection and cardiac disease.Active or prior documented autoimmune or inflammatory disorders (with exceptions).Active infection with tuberculosis, hepatitis B or C virus, hepatitis A, or known HIV infection that is not well controlled.History of active primary immunodeficiency.Clinically significant corneal disease.
StudyTROPION-Lung12
SponsorAstraZeneca
Conditions
Non-small cell lung carcinoma
Requirements
From 18 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT06564844
