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A Study to Investigate the Effect of Baxdrostat on Ambulatory Blood Pressure in Participants With Resistant Hypertension

212 patients around the world

Available in Spain, Argentina

This is a Phase III, multicentre, randomised, double-blind, placebo-controlled, parallel group study to evaluate the safety, tolerability and the effect of 2 mg baxdrostat versus placebo, administered once a day (QD) orally, on the reduction of ambulatory SBP in participants with rHTN, defined as BP targets not being achieved in an individual despite the use of at least 3 antihypertensive agents of different classes (at maximum tolerated dose in the judgement of the Investigator), one of which is a diuretic.

AstraZeneca

212Patients around the world

Requirements for the patient

To 130 Years

All Gender

Medical requirements

: Participant must be ≥ 18 years old, at the time of signing the informed consent.
Mean seated SBP on AOBPM of ≥ 140 mmHg and < 170 mmHg at Screening.
Have a stable regimen of ≥ 3 antihypertensive medications, from different therapeutic classes (at least one should be a diuretic), at maximum tolerated dose in the judgement of the Investigator, for at least 4 weeks prior to Screening (participants who do not meet this criterion may be rescreened at the Investigator's discretion). Beta blockers used to treat other conditions (ie, migraine, HF, coronary artery disease) should not be counted as an antihypertensive medication for the purpose of qualifying for this study.
Have eGFR ≥ 45 mL/min/1.73 m2 at Screening.
Serum potassium (K+) level ≥ 3.5 and < 5.0 mmol/L at Screening, determined as per central laboratory
Randomization Criteria: mean ambulatory SBP of ≥ 130 mmHg at randomisation.

: Mean seated SBP on AOBPM ≥ 170 mmHg at Screening.
Mean seated DBP on AOBPM ≥ 110 mmHg at Screening.
Serum sodium level < 135 mmol/L at Screening, as per central laboratory.
Participant has the following known secondary causes of hypertension: renal artery stenosis, uncontrolled or untreated hyperthyroidism, uncontrolled or untreated hypothyroidism, pheochromocytoma, Cushing's syndrome, aortic coarctation.
New York Heart Association functional HF class IV at Screening.
Persistent atrial fibrillation.

StudyBax24

SponsorAstraZeneca

Requirements

To 130 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT06168409