Last updated 15 days ago
A Study to Test an Oral Medicine, Belumosudil, in Combination With Corticosteroids in Participants at Least 12 Years of Age With Newly Diagnosed Chronic Graft Versus Host Disease.
260 patients around the world
Available in Spain, Brazil, Argentina, United States
Up to 5 years
Sanofi
4Research sites
260Patients around the world
This study is for people with
Graft versus Host Disease
Requirements for the patient
From 12 Years
All Gender
Medical requirements
- Patients must be at least 12 years of age inclusive, at the time of signing the informed consent.Participants who have undergone allogenic HCT with newly diagnosed moderate to severe cGVHD according to NIH consensus diagnosis and staging criteria (2014).Participants who require systemic treatment with corticosteroids for cGVHD.Participants who have not received any prior systemic treatment for cGVHD (including ECP).If participants are receiving other immunosuppressive agents for the prophylaxis or treatment of acute GVHD, the dose should be under the threshold pre-defined in protocol.Body weight ≥ 40kg.Contraceptive use by men and women should be consistent with local regulations regarding the methods of contraception for those participating in clinical studies.Participants or their legally authorized representative must be capable of giving signed informed consent.
- Recaída histológica de la enfermedad subyacente tras el TCH alogénico más reciente.Post-transplant lymphoproliferative disease within 4 weeks prior to randomization.Female participants who are pregnant or breastfeeding.Unable to tolerate a prednisone equivalent dose of corticosteroids ≥ 1 mg/kg/day.Participant has had previous exposure to belumosudil.Received any previous systemic treatment for cGVHD with the following exception: Corticosteroids for cGVHD received within 7 days prior to the planned administration of IMP only if in the interest of participant.Received any investigational agents, or any investigational device or procedure, or prohibited therapy for this study within 28 days or 5 elimination half-lives prior to randomization, whichever is longer Diagnostic assessments.Karnofsky (if aged ≥16 years)/Lansky (if aged <16 years) Performance Score of < 60.Platelets <50 x 109/L.Absolute neutrophil count (ANC) <1.0 x 109/L.Estimated Glomerular Filtration Rate (eGFR) <30 mL/min/1.73 m2 using the MDRD-4 variable formula (if aged ≥18 years) or using the Bedside Schwartz formula (if aged <18 years).Aspartate aminotransferase (AST) and/or alanine aminotransferase (ALT) >3 x ULN without liver cGVHD (or >5 × ULN if due to cGVHD with liver cGVHD).Total bilirubin >1.5 × (ULN) (>3 × ULN if Gilbert syndrome).Participant has forced expiratory volume in 1 second (FEV1) of predicted ≤39% or has lung score of 3 according to NIH consensus diagnostic and staging criteria (2014).History or other evidence of severe illness or any other conditions that would make the participant, in the opinion of the Investigator, unsuitable for the study (such as malabsorption syndromes, poorly controlled psychiatric disease or coronary artery disease).Known history of human immunodeficiency virus (HIV).Active viral disease including hepatitis B virus (HBV) or hepatitis C virus (HCV).Active uncontrolled cytomegalovirus (CMV) and Epstein-Barr virus (EBV) infection. Infections are considered controlled if appropriate therapy has been instituted and, at the time of screening, no signs of infection worsening are present according to Investigator's judgement.Diagnosed or treated for another malignancy other than the underlying disease allogeneic HCT was indicated for, within 3 years prior to randomization with the exception of complete resection of basal cell carcinoma or squamous cell carcinoma of the skin, an in-situ malignancy, or low risk prostate cancer after curative therapy.Unable to swallow tablets.Participant not suitable for participation, whatever the reason, as judged by the Investigator, including medical or clinical conditions, or participants potentially at risk of noncompliance to study procedures.Any active, uncontrolled infections assessed to be clinically significant by the Investigator.
Sites
CEMIC - Hospital Universitario Sede Saavedra - CABA, Buenos Aires
Recruiting
Hospital Británico de Buenos Aires - CABA
Recruiting
Instituto Médico Especializado Alexander Fleming - CABA, Buenos Aires
Recruiting
Hospital das Clínicas da Faculdade de Medicina da São Paulo - USP
Recruiting
StudyROCKnrol-1
SponsorSanofi
Conditions
Graft versus Host Disease
Requirements
From 12 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT06143891
