Last updated 15 months ago

Pilot Study: Oral Treatment of American Tegumentary Leishmaniasis (Cutaneous and Mucosal Forms) in the Elderly

100 patients around the world

Available in Brazil

University of Brasilia

100Patients around the world

Requirements for the patient

From 50 Years

All Gender

: Active confirmed cutaneous leishmaniasis ou mucosal leishmaniasis
Use of highly effective contraceptive method and a negative serologic pregnancy test (beta - HCG), if female in fertile phase
Agree and sing informed consent form

: Previous treatment with leishmanicidal drugs in the last 6 months
Pre-treatment electrocardiographic changes that contraindicate the use of liposomal amphotericin B (QTc greater than 450ms)
Serum creatinine or urea 1.5 times the upper limit of normal
Patients with severe or decompensated liver, kidney, heart disease, Diabetes Mellitus
history of any hypersensitivity reaction to liposomal amphotericin B, miltefosine and/or pentoxifylline
Pregnant and breastfeeding women
Patients with Acquired Immunodeficiency Syndrome (AIDS) or other immunodeficiency

SponsorUniversity of Brasilia

Requirements

From 50 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT06040489