Last updated 24 days ago

A Safety and Preliminary Efficacy Study of CC-99282, Alone and in Combination With Anti-lymphoma Agents in Participants With Relapsed or Refractory Non-Hodgkin Lymphomas (R/R NHL)

438 patients around the world
Available in Chile, Brazil, Argentina
Participants with relapsed or refractory non-Hodgkin's lymphomas (R/R NHL) who have failed at least 2 lines of therapy (or have received at least one prior line of standard therapy and are not eligible for any other therapy). The dose escalation will evaluate the safety and tolerability of escalating doses of CC-99282 in relapsed or refractory diffuse large B-cell lymphoma (R/R DLBCL) and/or relapsed or refractory follicular lymphoma (R/R FL) participants to determine the maximum tolerated dose (MTD) of CC-99282 as monotherapy. The dose expansion will further evaluate the safety and preliminary efficacy of single agent CC-99282 or the safety and preliminary efficacy of CC-99282 in combination with anti-lymphoma agents in participants with R/R DLBCL and NHL. Part B Cohort B will further evaluate the potential effects of food on the PK and safety of CC-99282.
Celgene
9Research sites
438Patients around the world

This study is for people with

Lymphoma
Non-Hodgkin lymphoma

Requirements for the patient

From 18 Years
All Gender

Medical requirements

History of Non-Hodgkin's Lymphoma (NHL) with relapsed or refractory disease
Has an Eastern Cooperative Oncology Group (ECOG) performance status of 0, 1 or 2
Life expectancy ≤ 2 months
Received prior systemic anti-cancer treatment (approved or investigational) ≤ 5 half-lives or 4 weeks prior to starting CC-99282, whichever is shorter
Is on chronic systemic immunosuppressive therapy or corticosteroids or has clinically significant graft-versus-host disease (GVHD)
Impaired cardiac function or clinically significant cardiac disease

Sites

CEMIC - Hospital Universitario Sede Saavedra - CABA, Buenos Aires
CEMIC - Hospital Universitario Sede Saavedra - CABA, Buenos Aires
Recruiting
Av. Galvan 4102, CABA, Buenos Aires
Hospital Alemán
Recruiting
Av. Pueyrredón 1640, CABA, Buenos Aires
Instituto D'Or de Pesquisa e Ensino - Sao Paulo
Recruiting
Av. República do Líbano, 611 - Ibirapuera, São Paulo - SP, 04501-000
Hospital Israelita Albert Einstein - Fortaleza, Ceara
Recruiting
Avenida Albert Einstein 627/701, 2° Subsolo - Bloco A, Centro de Pesquisa Clínica, São Paulo, Sao Paulo
Hospital São Lucas da Pontifícia Universidade Católica do Rio Grande do Sul
Recruiting
Av. Ipiranga, 6690 - 4º andar - Partenon, Porto Alegre - RS, 90610-001, Brazil
Centro de Investigación Clínica Bradford Hill - Santiago, Región Metropolitana
Centro de Investigación Clínica Bradford Hill - Santiago, Región Metropolitana
Recruiting
Manzano 343, Recoleta, Región Metropolitana, Santiago
Fundación Arturo López Pérez
Recruiting
José Manuel Infante 805, Providencia, Región Metropolitana
Centro de Oncología de Precisión
Recruiting
Santiago, Región Metropolitana de Santiago, 7560908
Inmunocel
Recruiting
Av. Pdte. Kennedy 5488, 7630716 Vitacura, Región Metropolitana, Chile
LinkedinInstagramFacebook
Terms and ConditionsPrivacy Policy