Last updated 16 days ago

A Study of Nemtabrutinib vs Chemoimmunotherapy for Participants With Previously Untreated Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (CLL/SLL) Without TP53 Aberrations (MK-1026-008, BELLWAVE-008)

300 patients around the world

Available in Brazil, Chile

Merck Sharp & Dohme LLC

8Research sites

300Patients around the world

This study is for people with

Leukemia

Chronic lymphocytic leukemia

From 18 Years

All Gender

: Confirmed diagnosis of chronic lymphocytic leukemia (CLL)/ small lymphocytic lymphoma (SLL) and active disease clearly documented to have a need to initiate therapy
Has previously untreated CLL/SLL participants without tumor protein 53 (TP53) aberrations and documented 11q status and immunoglobulin heavy chain gene (IGHV) mutational status
The ability to swallow and retain oral medication

: Active hepatitis B virus (HBV) or hepatitis C virus (HCV) infection
Gastrointestinal dysfunction that may affect drug absorption (eg, gastric bypass surgery, gastrectomy)
Known additional malignancy that is progressing or has required active treatment within the past 3 years, except basal cell carcinoma of skin, squamous cell carcinoma of skin, or carcinoma in situ (eg, breast carcinoma, cervical cancer in situ) that have undergone potential curative therapy
History of severe bleeding disorders
Not adequately recovered from major surgery or has ongoing surgical complications

Hospital Paulistano

Recruiting

Sao Paulo, 01321-001

Centro de Pesquisas Clinicas da Fundacao Doutor Amaral Carvalho

Recruiting

Jau, 17210080

Instituto do Câncer do Estado de São Paulo "Octavio Frias de Oliveira" - ICESP

Recruiting

Av. Dr. Arnaldo, 251 - Consolação, São Paulo - SP, 01255-090, Brazil

IC La Serena Research - La Serena

Recruiting

Woodrow Wilson 1697, La Serena, Chile

James Lind Centro de Investigación del Cáncer - Temuco

Recruiting

Hochstetter 298, Temuco

Instituto Oncológico FALP - UIDO

Recruiting

José Manuel Infante 805, Providencia, Región Metropolitana

Biocenter

Recruiting

Concepción, Biobio 4070196

Centro de Estudios Clínicos SAGA - CECSAGA

Recruiting

Antonio Varas 517, 7500653 Providencia, Región Metropolitana

SponsorMerck Sharp & Dohme LLC

Conditions

Chronic lymphocytic leukemia

Requirements

From 18 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT05624554