Last updated 16 months ago
Candesartan Cilexetil + Chlorthalidone + Amlodipine Versus Exforge HCT®️ for Systemic Arterial Hypertension
698 patients around the world
Available in Brazil
This phase III, multicenter, randomized, double-blind, controlled, parallel trial will
evaluate the non-inferiority of the association between candesartan cilexetil 16mg +
chlorthalidone 12.5mg + amlodipine 5mg in relation to Exforge HCT® (valsartan 160mg +
hydrochlorothiazide 12 5mg + amlodipine 5mg) in the treatment of systemic arterial
hypertension. A total of 698 participants will be included. Follow-up visits will occur four,
eight, and twelve weeks after the date of the randomization visit. A telephone contact will
be performed 30 days after the end of treatment. The primary efficacy outcome is the mean
change in blood pressure, measured at the research site, 12 weeks after starting treatment,
compared to baseline. Incidence of adverse events will be collected from the first dose of
treatment up to 30 days after the end of the treatment foreseen in the protocol.
Hospital Israelita Albert Einstein
11Research sites
698Patients around the world
This study is for people with
Arterial hypertension
Systemic arterial hypertension
Requirements for the patient
From 18 Years
All Gender
Medical requirements
- Both genders aged 18 years or older;Currently on dual antihypertensive therapy for at least 8 weeks, and non responders to that treatment, defined as measurements of SBP ≥ 140 mmHg and ≤180 mmHg and/or DBP≥90mmHg and ≤110 mmHg, assessed at the screening visit and randomization visit (both conditions are in accordance with the Brazilian Hypertension Guideline - 2020);Able to understand and consent to their participation in this clinical trial, manifested by signing the Informed Consent Form;
- Any significant clinical condition that, in the investigator's opinion, may interfere with participant safety;Any laboratory test finding that, in the investigator's opinion, may interfere with participant safety;Suspected or diagnosed with COVID 19;History of hypersensitivity to components of drugs used during the trial or to drugs derived from sulfonamides;Pregnant or breastfeeding women;Women in a reproductive age who do not agree to use contraceptive methods;Male participants who do not agree to use contraceptive methods;Participation in clinical trial protocols in the last 12 (twelve) months, unless the investigator judges that there may be a direct benefit to the participant;Participant who has some kind of relationship up to the second degree or bond with collaborators or employees of the Sponsor and the Research site;Estimated glomerular filtration rate (eGFR) less than 45 ml/min /1.73m2 (calculated by the Chronic Kidney Disease Epidemiology Collaboration [CKD-EPI] equation) or end-stage renal disease;Severe liver dysfunction;Cardiogenic shock or reduced ejection fraction heart failure with a left ventricular ejection fraction less than or equal to 50%;Symptomatic congestive heart failure class II, III or IV, according to the New York Heart Association and/or participants with a history of infarction, unstable angina or cerebrovascular accident in the last 6 months prior to the beginning of the study;Clinically relevant ventricular cardiac arrhythmias;Obstructive coronary artery disease;Dementia syndrome;History of alcohol or illicit drug addiction in the six months prior to the date of signature of the Informed Consent Form;Obstructive biliary disorders;Refractory hypokalemia and/or conditions involving marked potassium loss, hyperkalemia, and/or hyponatremia;History of symptomatic hyperuricemia;History of secondary hypertension;History of cancer, without documentation of remission/cure;
Sites
Hospital Universitário João de Barros Barreto
Hospital Nove de Julho
Instituto Atena de Pesquisa Clínica
Hospital São Francisco de Assis - BH
Instituto De Pesquisa Clinica de Campinas - Ipecc
Santa Casa de Misericórdia de Passos
Hospital de Clínicas de Porto Alegre
Hospital Universitario Pedro Ernesto
Instituto do Coração do HCFMUSP
Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas / Clinica Popular Endocrinologia
StudyOPTION TREAT
SponsorHospital Israelita Albert Einstein
Conditions
Systemic arterial hypertension
Requirements
From 18 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT05920005
