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A Study of MK-1084 Plus Pembrolizumab (MK-3475) in Participants With KRAS G12C Mutant, Metastatic Non-small Cell Lung Cancer (NSCLC) With Programmed Cell Death Ligand 1 (PD-L1) Tumor Proportion Score (TPS) ≥50% (MK-1084-004)
600 patients around the world
Available in Chile, United States, Argentina
Merck Sharp & Dohme LLC
5Research sites
600Patients around the world
This study is for people with
Lung cancer
Non-small cell lung carcinoma
Requirements for the patient
From 18 Years
All Gender
Medical requirements
- Has a histologically or cytologically confirmed diagnosis of NSCLC.Has newly diagnosed Stage IV NSCLC by American Joint Committee on Cancer (AJCC) Staging Manual, Version 8.Has measurable disease based on RECIST 1.1.Has provided tumor tissue that demonstrates PD-L1 expression in ≥50% of tumor cells.Has provided tumor tissue that demonstrates presence of KRAS G12C mutation.Has life expectancy of at least 3 months.Has Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 assessed within 7 days before randomization.For participant assigned male sex at birth: If capable of producing sperm, participant must agree to the following during the study treatment period and for at least 10 days after the last dose of oral intervention: Either be abstinent or must agree to use male condom plus additional contraceptive method.For participant assigned female sex at birth: Either be a person of nonchildbearing potential (PONCBP) or must agree to follow contraceptive guidance during the study treatment period and for at least 10 days after the last dose of oral intervention and 120 days after the last dose of pembrolizumab.Human immunodeficiency virus (HIV)-infected participants must have well controlled HIV on antiretroviral therapy (ART).Participants who are hepatitis B surface antigen (HBsAg) positive are eligible if they have received hepatitis B virus (HBV) antiviral therapy for at least 4 weeks and have undetectable HBV viral load before randomization.
- Diagnosis of small cell lung cancer.Has active inflammatory bowel disease requiring immunosuppressive medication or previous clear history of inflammatory bowel disease.Has a known history of, or active, neurologic paraneoplastic syndrome.Has an active infection requiring systemic therapy.Has uncontrolled, significant cardiovascular disease or cerebrovascular disease including New York Heart Association Class III or IV congestive heart failure, unstable angina, myocardial infarction, uncontrolled symptomatic arrhythmia, prolongation of QT interval corrected for heart rate by Fridericia's formula (QTcF) interval to >470 ms, and/or other serious cardiovascular and cerebrovascular diseases within the 6 months preceding study intervention.Is considered a poor medical risk due to a serious, uncontrolled medical disorder or nonmalignant systemic disease.Has one or more of the following ophthalmological findings/conditions: intraocular diagnosis of central serous retinopathy, retinal vein occlusion, or retinal artery occlusion, diagnosis of retinal degenerative disease pressure >21 mm Hg and/or any diagnosis of glaucoma.Is unable to swallow orally administered medication, or has a gastrointestinal disorder affecting absorption (eg, gastrectomy, partial bowel obstruction, or malabsorption).Received prior systemic anticancer therapy for their metastatic NSCLC.Received prior therapy with an anti-programmed cell death-1 (anti-PD-1), anti-programmed cell death-ligand 1 (anti-PD-L1), or anti PD-L2 agent, or with an agent directed to another stimulatory or coinhibitory T-cell receptor within 12 months before diagnosis of metastatic NSCLC.Has received radiotherapy within 2 weeks of start of study intervention.Has received a live or live-attenuated vaccine within 30 days before the first dose of study intervention. Administration of killed vaccines is allowed.Has received an investigational agent or has used an investigational device within 4 weeks prior to study intervention administration.Has known active central nervous system (CNS) metastases and/or carcinomatous meningitis.Diagnosis of immunodeficiency or is receiving chronic systemic steroid therapy (in dosing exceeding 10 mg daily of prednisone equivalent) or any other form of immunosuppressive therapy within 7 days prior to the first dose of study intervention.Active autoimmune disease that has required systemic treatment in the past 2 years.History of (noninfectious) pneumonitis/interstitial lung disease that required steroids or has current pneumonitis/interstitial lung disease.HIV-infected participants with a history of Kaposi's sarcoma and/or Multicentric Castleman's Disease.History of allogeneic tissue/solid organ transplant.Has not fully recovered from any effects of major surgical procedure. Surgical procedures that required general anesthesia must be completed at least 2 weeks before first study intervention administration.
Sites
Centro Médico Austral OMI - CABA
Recruiting
Centro Oncológico Korben
Recruiting
Sanatorio Parque - Rosario
Recruiting
Instituto Oncológico FALP - UIDO
Recruiting
Centro de Oncología de Precisión
Recruiting
StudyMK-1084-004
SponsorMerck Sharp & Dohme LLC
Conditions
Non-small cell lung carcinoma
Requirements
From 18 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT06345729
