Last updated 3 days ago
Study Evaluating Tarlatamab After Chemoradiotherapy in Limited-Stage Small-Cell Lung Cancer (LS-SCLC)
400 patients around the world
Available in Spain, Brazil, Argentina, Mexico, United States
Amgen
6Research sites
400Patients around the world
This study is for people with
Lung cancer
Small cell lung carcinoma
Requirements for the patient
From 18 Years
All Gender
Medical requirements
- Participants are eligible to be included in the study only if all of the following criteria apply.Participant has provided informed consent prior to initiation of any study specific activities/procedures.Age ≥ 18 years (or ≥ legal age within the country if it is older than 18 years).Histologically or cytologically confirmed small-cell lung cancer (SCLC).Diagnosed and treated for LS-SCLC with concurrent chemotherapy and radiotherapy.Has completed chemoradiotherapy without progression per Response Evaluation Criteria in Solid Tumors v1.1 (RECIST 1.1) (ie, achieved complete response [CR], partial response [PR], or stable disease [SD]).Eastern Cooperative Oncology Group (ECOG) Performance Status (PS) of 0 or 1.Minimum life expectancy of 12 weeks.Adequate organ function.Toxicities attributed to concurrent chemoradiotherapy resolved to grade ≤ 1 unless otherwise specified.
- Participants are excluded from the study if any of the following criteria apply.Extensive-stage SCLC (ES-SCLC).Any previous diagnosis of transformed non-small-cell lung cancer (NSCLC), epidermal growth factor receptor (EGFR) activating mutation positive NSCLC that has transformed to SCLC, or mixed SCLC NSCLC histology.Evidence of interstitial lung disease or active, non-infectious pneumonitis.History of other malignancy within the past 2 years with certain exceptions.History of solid organ transplantation.Myocardial infarction and/or symptomatic congestive heart failure (New York Heart Association > class II) within 6 months prior to first dose of study treatment.History of arterial thrombosis (eg, stroke or transient ischemic attack) within 6 months prior to first dose of study treatment.Exclusion of human immunodeficiency virus (HIV) and/or hepatitis infection based on criteria per protocol.Participant with symptoms and/or clinical signs and/or radiographic signs that indicate an acute and/or uncontrolled active systemic infection within 7 days prior to the first dose of study treatment.Received sequential chemotherapy and thoracic radiotherapy (no overlap of thoracic radiotherapy with chemotherapy) during chemoradiation.Prior therapy with any selective inhibitor of the delta-like ligand 3 (DLL3) pathway.Prior history of severe or life-threatening events from any immune-mediated therapy.Receiving another anti-cancer therapy. Adjuvant hormonal therapy for resected breast cancer is permitted.Receiving systemic corticosteroid therapy or any other form of immunosuppressive therapy within 7 days prior to enrollment.Major surgical procedures within 28 days prior to first dose of study treatment.Treatment with live virus, including live-attenuated vaccination, within 14 days prior to the first dose of study treatment.Inactive vaccines and live viral non-replicating vaccines within 3 days prior to first dose of study treatment.Treatment in an alternative investigational trial within 28 days prior to enrollment.Female participants of childbearing potential unwilling to use protocol specified method of contraception during treatment and for an additional 60 days after the last dose of study treatment.Female participants who are breastfeeding or who plan to breastfeed while on study through 60 days after the last dose of study treatment.Female participants planning to become pregnant or donate eggs while on study through 60 days after the last dose of study treatment.Female participants of childbearing potential with a positive pregnancy test assessed at screening by a highly sensitive serum pregnancy test.Male participants with a female partner of childbearing potential who are unwilling to practice sexual abstinence or use contraception during treatment and for an additional 60 days after the last dose of study treatment.Male participants with a pregnant partner who are unwilling to practice abstinence or use a condom during treatment and for an additional 60 days after the last dose of study treatment.Male participants unwilling to abstain from donating sperm during treatment and for an additional 60 days after the last dose of study treatment.Participant has known sensitivity to any of the products or components to be administered during dosing.Participant likely to not be available to complete all protocol-required study visits or procedures and/or to comply with all required study procedures to the best of the participant and investigator's knowledge.History or evidence of any other clinically significant disorder, condition, or disease that, in the opinion of the investigator or Amgen physician, if consulted, would pose a risk to participant safety or interfere with the study evaluation, procedures or completion.
Sites
Fundación Respirar
Recruiting
Hospital Alemán
Recruiting
Sanatorio 9 de Julio - Tucumán
Recruiting
Hospital Ana Nery
Recruiting
Hospital Amaral Carvalho
Recruiting
Centro de Estudos e Pesquisas de Hematologia e Oncologia - CEPHO
Recruiting
StudyDeLLphi-306
SponsorAmgen
Conditions
Small cell lung carcinoma
Requirements
From 18 YearsAll Gender
Unique study IDclinicaltrials.gov
NCT06117774
