Last updated 27 days ago

A Study to Evaluate the Safety and Effectiveness of Upadacitinib Tablets in Adult and Adolescent Participants With Severe Alopecia Areata

1500 patients around the world

Available in Puerto Rico, Brazil, United States, Chile

AbbVie

10Research sites

1500Patients around the world

This study is for people with

Alopecia

Alopecia areata

Requirements for the patient

To 63 Years

All Gender

Medical requirements

: Adult individuals must be < 64 years old at Baseline Visit. Where permitted outside United States (OUS), adolescent individuals who are at least 12 years old at Screening may participate.
Diagnosis of severe alopecia areata (AA) with Severity of Alopecia Tool (SALT) score >= 50 scalp hair loss at Screening and Baseline.
Severe AA with no spontaneous scalp hair regrowth over the past 6 months AND no significant scalp hair loss over the past 3 months.
Current episode of AA of less than 8 years.

: Diagnosis of primarily diffuse type of AA.
Diagnosis of other types of alopecia that would interfere with evaluation of AA, including but not limited to female pattern hair loss, male pattern hair loss (androgenetic alopecia) Stage III or greater based on Hamilton-Norwood classification, traction alopecia, lichen planopilaris (LPP), discoid lupus, frontal fibrosing alopecia (FFA), central centrifugal cicatricial alopecia (CCCA), folliculitis decalvans, trichotillomania, and telogen effluvium.
Diagnosis of other types of inflammatory scalp, eyebrow, or eyelash disorders that would interfere with evaluation of AA, including but not limited to seborrheic dermatitis, scalp psoriasis, atopic dermatitis (AD), and tinea capitis.

Sites

CIPREC Centro de Investigación y Prevención Cardiovascular - CABA

Recruiting

Av. Pueyrredon 1746, CABA, Buenos Aires

Instituto de Investigaciones Clínicas Córdoba

Recruiting

Dean Funes 1161, Córdoba

Psoriahue Medicina Interdisciplinaria - CABA, Buenos Aires

Recruiting

Bulnes 1937, CABA, Buenos Aires

Centro Médico - Buenos Aires Skin S.A. - CABA, Buenos Aires

Recruiting

Av. Córdoba 1184, CABA, Buenos Aires

Instituto de Neumonología y Dermatología Dr. Luna

Recruiting

Arenales 2557, CABA, Buenos Aires

Hospital Alemão Oswaldo Cruz

Recruiting

R. Treze de Maio, 1815 - Bela Vista, São Paulo - SP, 01323-020, Brazil

Instituto Brasil de Pesquisa Clínica - IBPClin

Recruiting

R. da Glória, 344 - Glória, Rio de Janeiro - RJ, 20241-180

Irmandade da Santa Casa de Misericórdia de Porto Alegre

Recruiting

Rua Professor Annes Dias - Centro Histórico, Porto Alegre - RS, 90020-090, Brazil

Clínica Dermacross S.A. - Vitacura - Santiago

Recruiting

Av. Manquehue Norte 2051 C, Vitacura, Metropolitana, 7640881

Centro Internacional de Estudios Clínicos - CIEC

Recruiting

Calle Manzano 343, Oficina 410-411, Comuna de Recoleta, Región Metropolitana, 8420383

StudyUp-AA

SponsorAbbVie

Conditions

Alopecia areata

Requirements

To 63 YearsAll Gender

Unique study IDclinicaltrials.gov

NCT06012240